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PhD distress 2nd yr
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Get as much feedback as you can! I've read many times on this site about supervisors being unwilling to read work, so it's great that your supervisors are so involved. It will help improve your work. Some feedback is useless of course, so don't feel you have to incorporate every suggestion.

Can you get a statistician to do the calculations for your study?
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I would very much doubt you'd get a statistician to agree to this! As part of the PhD you need to learn how to conduct research, so acquiring these skills is vital. There should be courses for training in SPSS. My supervisor didn't know about the particular techniques I was employing - it will often be the case you need to ask for help from other people.

Dr or Mrs on job application?
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Definitely important to state somewhere that you have your viva and the result. Some institutions are quite finicky, one I was going to apply to only counted "having the PhD" as having had the award confirmed by Senate. Ridiculous I know.

Dr or Mrs on job application?
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Technically until the award is conferred by Senate (or the equivalent), you cannot call yourself Doctor (even when the corrections are accepted).

Applying for several positions simulataneously?
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Absolutely nothing wrong with applying for several posts simultaneously. It's what you have to do. The only caution is that the more you do, the less polished (and specific) each application tends to be - so it may be in your interest to not do too many.
I was in an awkward situation where it looked like the interview for one job would come before the interview for the job I preferred. Personally I wouldn't accept the first job then go to the second interview in the hope of getting my preferred job, but I know lots of people would.

First week PhD - Disappointment
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I am reminded of an excellent quotation of Albert Einstein
If we knew what it was we were doing, it would not be called research, would it?

First week PhD - Disappointment
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Remember the PhD is a marathon not a sprint!
Just break the PhD down into tasks. The first task is getting research training and deciding on your exact research question(s). Looking at the whole thing will seem daunting.
So don't have too high expectations for your first month.
I'm feeling the same way after my first week of a Postdoc, and having to tell myself the same things.

Going from 2nd author to 5th author
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It's understandable and perfectly fair that the contribution of others has been reflected in authorship. There is a lot of work in preparing a manuscript for publication.

To apply or not to that is the question
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Do they "wish" for that experience or require it? Either way, I tend to agree with ToL. There's such a tight job market, applying for posts where you don't fit the criteria is likely to dishearten you.

research design advice for clinical research
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Why would a control group be unethical?

Finishing PhD Early?
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Chococake's advice is excellent. It is always good to go back to a piece of work after some time ('drawer time').

Viva next week: tips and advice for before and during?
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I imagine every viva's different. There are questions you're very likely to be asked like "why this project?", "what are your main findings?" , "where does this research lead next?" , "why did you choose this methodology?"
It's also OK to say "I don't know". My external asked me if a particular legal decision contradicted one of my conclusions, and I said I didn't think so because of A but I would go back and read the case again. Better than seeming a know-it-all or arrogant I think.
Above all, remember the results rests on the thesis. Your performance in the viva is probably neither here nor there.

Finishing PhD and feeling low
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The end of the PhD is difficult even without the personal loss you have suffered, for which you have my condolences. So often family and friends are so instrumental in helping someone through the PhD. And yes, thinking about the next step is quite daunting. It is not easy getting an academic job or postdoc, you have to persevere. I had given up getting a job for this academic year, but I have just landed something. Away from home, but having a job is the most important thing. I'm sure your sister would have been immensely proud of you.

2:2 BSc and MSc, should I not bother to apply to Oxbridge at all?
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Yes, obtaining a good supply of tea is essential! Hence why USA out of the question.

Extreme journal club fear
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Good point about beta-blockers - I've taken them for important vivas or job interviews and really helped me.