I am: most of the time it's fine, but sometimes I get a box with 2000 samples in that "need" analysing by yesterday, and then you have to drop everything and do it. I also have to present progress to a board every month.
The major difficulty for me is when instruments are not working: if I was just doing a normal PhD, I would be the only one affected - but as it is, I get angry emails from businessmen asking why I am not doing the work I'm being paid to do. Explaining that your uni is slow to fix things does not go down well