I know someone who did Physics/Molecular Biology. I would expect it to be a struggle as he didn't have any background in Molecular Biology and had to learn the labwork from scratch. It depends how much emphasis there is on each department, e.g. is it just a year or a short project in one department. Could mean more work as widens what you need to know. Also whether the supervisors are going to really care about your progress and make sure you learn everything and not just leave you to it. I know someone else with supervisors at different unis, who did his 1st year in our lab, then finished at the other lab (similar departments). He did fantastically well in his 1st year (jammy), but his other supervisor was really unpleasant. He's finished and has a job in a brewery now(jammy).
There is the view that subjects have more cross-over now, and the different approaches give a new angle that no-one would have found otherwise.