If you are targeting for a funded position, you may find that you are competing against those with better academic results, eg. First class honour in BSc and Distinction in masters. Therefore, you may face challenges to get in.
You may wish to consider interning or working as a RA/technician in the lab or field that you are interested in to build relationship and gain skills that are valuable for your PhD. Thay may be your trump card to overcome your challenges of other candidates with better academic achievements.