Hi I'm 3 years into a PhD in organic chemistry which had very little basis from the beginning but I was too naive to know that. I was so excited when I started my PhD and was really enthusiastic (I know, we've all been there!) but now I find it hard to go into the lab everyday. I have hardly any results so far and am not sure how long more I can continue on for. Does anybody have any idea roughly how many new molecules you need to synthesise for a PhD? Is it ok to submit a PhD where nothing worthwhile has worked but you've tried lots of different routes?