YES!!!! To put it simply. I am sure it depends on the field, where you live, what your PhD was in etc. But, I am in this situation right now, and it is proving downright impossible for me to get a job just one tiny step removed from my PhD topic, even though the jobs I am applying for require the same skills that my PhD has given me. And I am not even dreaming of applying for postdoc positions, instead I am going for research assistant/research associate jobs at unis which do not even require a PhD.