Oh god I don't know where to start. I am just finishing my phd, 3.5 years. Thesis written and starting corrections from my supervisors. The main bulk of my work is in a single paper which has now been rejected three times by various journals. Last week I was diagnosed with depression and anxiety by my gp. I have started medication. I don't think I will get my phd because three journals think my work does not contribute significantly to the current knowledge. I have one paper published as first author but it is not entirely related to my phd. I am second co author on two papers again not directly related to my phd. I don't know whether to pack it in now or continue submitting this paper. My supervisors think it is adding to the current knowledge but I don't think any other scientist in our field thinks it is of any benefit. What should I do?