Depends if it is sicence or hummanities. If hummanties then obviously you need to have a good propsoal as MistaG says, and so number is prob less important than quality of proposal.
If science you will probably only be responding to projects thought up by others, so in this case you can apply to as many that interest you. Sciences tend to have a lot of PhD places, so you could conceivible apply to lots before finding one you like/getting accepted. Of course you still need to demostrate that you are motivated and interested in the subject.
Well to be honest I have been applying mostly for topics related to cancer, you can add a line that is specyfic but most of it is similar. At first I honestly wrote an individual cover letter for everything, later, when I was desperate I started copying and pasting and guess what? I started getting replies.
I applied for 26 (including some I would never be considered for because I am not qualified for them), got 3 interviews which I attended and three which I rejected once offered a place. One interview invitation was in January and all the five remaining from end June to mid August. I was surprised coz on this site it states that the later the more competitive, but quite a lot of institutes urgently searches for students at the beginning of summer.
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