Which is a better option for bioinformatics: PhD at Iowa State University or PhD at Virginia Tech?

I've received fully-funded admits for PhD in Bioinformatics at both Iowa State and Virginia Tech. I would like to work on genomics utilizing machine learning, networks biology, systems level analysis and the likes.

I'll have a chance to do 3 rotations at Iowa State before I choose my advisor. I will also have an opportunity to do a summer internship in my first year, since it is a part of their course itself.

On the other side, my advisor at Virginia Tech is a newly appointed assistant faculty who is tenure-track. I am his first and only recruitment this year. His background is however in evolutionary biology though he insists that I'm free to continue working on my present theme of something similar to that. Would it wise to be under him considering his primary interest is completely different than mine?

Which would be a better pick among these two universities? I'm not inclined towards teaching after my PhD, however research scientist at a laboratory or in industry is still good for me.

How do these compare with each other in terms of future opportunities, networking, internship prospects, success rate, location, reputation etc?

Should I join my to be advisor if he has a background in a very different domain, in evolutionary biology, than my research interests like genomics, machine learning, predictive modeling, systems biology, and cancers?

He says that he is recruiting me so that I can work on cancers. He has some great ideas about evolutionary biology and cancers but no prior experience in what I'm currently doing or wish to do.

He insists that I'll be free to continue what I'm doing or do something related which I'm interested in. So, would it be wise to join him considering his background is entirely different? I have no affinity for evolutionary biology.

Note: I've another offer from a university where I can do lab rotations and then pick up on my advisor.