Thank you for your replies, I really appreciate it. I have kept with the corrections my supervisors have given me for my first few chapters but with my paper continuously being rejected it is very hard to feel that the time I am investing in writing an correcting is really getting me anywhere. Regarding my paper the first journals reviewers stated that the study was quite complete with a large amount of data collected and characterisation experiments carried out however the end result did not add anything of significant advance in the area. The second journals reviewers thought the entire study was long winded, a waste, too much detail and data that was not adding to the current knowledge etc. The third journal rejected at editorial point prior to review but recommended the work for a member journal that does not have an impact factor. This is see at present as a reflection of the potential that my phd has of passing the viva. I am at my wits end with the entire thing.

Oh god I don't know where to start. I am just finishing my phd, 3.5 years. Thesis written and starting corrections from my supervisors. The main bulk of my work is in a single paper which has now been rejected three times by various journals. Last week I was diagnosed with depression and anxiety by my gp. I have started medication. I don't think I will get my phd because three journals think my work does not contribute significantly to the current knowledge. I have one paper published as first author but it is not entirely related to my phd. I am second co author on two papers again not directly related to my phd. I don't know whether to pack it in now or continue submitting this paper. My supervisors think it is adding to the current knowledge but I don't think any other scientist in our field thinks it is of any benefit. What should I do?

Oh god I don't know where to start. I am just finishing my phd, 3.5 years. Thesis written and starting corrections from my supervisors. The main bulk of my work is in a single paper which has now been rejected three times by various journals. Last week I was diagnosed with depression and anxiety by my gp. I have started medication. I don't think I will get my phd because three journals think my work does not contribute significantly to the current knowledge. I have one paper published as first author but it is not entirely related to my phd. I am second co author on two papers again not directly related to my phd. I don't know whether to pack it in now or continue submitting this paper. My supervisors think it is adding to the current knowledge but I don't think any other scientist in our field thinks it is of any benefit. What should I do?